Cisplatin and transplatin

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August undefined, 2024

WebFeb 17, 2009 · The behaviour of cisplatin in serum, and the drastic differences between the properties of this drug and its trans-isomer were the main motivations for this work. In a search for model “thiol–platin(II)” interactions, the first steps of the following reaction systems were evaluated: (1) cisplatin–thiomethanol; (2) transplatin–thiomethanol; (3) … Webcis- and trans- [PtX (NH3)2(H2O)]+ (X = Cl, OH) complexes, formed in solution by stepwise hydrolysis of the respective precursors, cisplatin and transplatin, cis- and trans-PtCl2(NH3)2, have been allowed to react with …

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WebJun 18, 2009 · A geometrical isomer of cisplatin, trans -diamminedichloridoplatinum (II) (transplatin), is clinically inactive. This is believed to be due mainly to its inability to form similar DNA adducts as cisplatin [ 4 ]. The resistance of cancer cells to Pt (II) drugs can be either intrinsic or acquired following Pt (II) administration [ 1 ]. churches in the buffalo ny area

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WebThe stability of cisplatin in the solutions was determined by measuring the concentrations of cisplatin, trichloroammineplatinate(II) (TCAP), and trans-dichlorodiammineplatinum(II) (transplatin) with high-performance liquid chromatography and by measuring solution pH. The effect of adding ethylene oxide and other materials was also determined. WebThe lack of anticancer activity with transplatin is believed to be because transplatin lesions are more easily repaired than those of cisplatin, as they lead to more radical distortion of DNA. They don’t bind HMG proteins as strongly as cisplatin lesions, … WebDec 19, 2024 · To investigate the effects of cisplatin and transplatin on the higher-order structure of DNA, we used FM to observe single DNA molecules in the presence or absence of cisplatin or transplatin. Typical FM images and corresponding quasi-3D … development stage at the time of sampling

Hydrolysis of cis- and transplatin: structure and reactivity …

Transplatin - Wikipedia

WebDiamminedchloroplatinum(II) (Cisplatin), discovered at Michigan State University by Barnett Rosenberg in 1969. In this experiment, a number of Pt(II) complexes are synthesized, resulting in the synthesis of both Cisplatin and Transplatin. The synthesis of Cisplatin … WebMolecular structure, IR spectra, and chemical reactivity of cisplatin and transplatin DFT studies, basis set effect and solvent effect.pdf. 2015-10-16 ... churches in the metaverseWebDec 19, 2024 · The inhibitory effect of cisplatin on gene expression was about 7 times that of transplatin. Analysis of the fluctuation autocorrelation function of the intrachain Brownian motion of individual DNA molecules showed that cisplatin increases the spring … development stage of children

"WebFeb 1, 2007 · It is widely accepted that transplatin inactivity stems from two major factors: i) the kinetic instability promoting its deactivation and ii) the formation of DNA adducts characterized by a... " - Cisplatin and transplatin

Cisplatin and transplatin

An Ultraviolet Resonance Raman Spectroscopic Study of Cisplatin …

WebApr 14, 2024 · Non-radioactive reference samples, K 2 Pt II Cl 4 prepared in 0.1 mol/L HCl (0.5 mg/mL), and non-radioactive cisplatin and transplatin in saline solution (0.5 mg/mL) were also analyzed to identify ... WebThe thermodynamics of cisplatin and transplatin hydration is studied within the model of constant pH solution. Several implicit solvation models were chosen for the determination of pK(a) and pK constants of the hydration reactions. The polarizable dielectric model (DPCM), integral equation formalis …

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Webtrans -Dichlorodiammineplatinum (II) has had far less impact on medicinal chemistry compared to its cis isomer, cisplatin, which is a major anticancer drug. Nonetheless, replacement of the ammonia with other ligands has led to highly active drugs that have … WebDec 19, 2024 · Despite the effectiveness of cisplatin as an anticancer agent, its trans-isomer, transplatin, is clinically ineffective. Although both isomers target nuclear DNA, there is a large difference in the magnitude …

WebTransplatin, the trans -stereoisomer of cisplatin, has formula trans - [PtCl 2 (NH 3) 2] and does not exhibit a comparably useful pharmacological effect. Two mechanisms have been suggested to explain the reduced … WebJul 14, 2014 · Cisplatin (cis-[PtCl 2 (NH 3) 2]), carboplatin ([Pt ... Transplatin is the “inactive” geometric isomer of cisplatin , and [PtCl 2 (en)] is regularly used in experimental papers, and like cisplatin contains two cis-chlorido leaving groups . Figure 1. View large Download slide.

Webactivity of cisplatin. Aqua complexes [PtX(NH 3) 2(H 2O)] + (X ¼Cl, OH), obtained in water by hydrolysis of cisplatin and of the inactive isomer transplatin, are transferred into the gas-phase by electrospray ionization. The so-formed ions, cis- and trans-[PtX(NH 3) 2(H 2O)] +, have been allowed to react with WebJun 17, 1997 · The first step of the reaction between DNA and the antitumor drug cisplatin or its clinically inactive isomer transplatin yields monofunctional adducts. Most of the cisplatin monofunctional adducts further react and rather rapidly (t1/2 smaller than a few hours) to form intrastrand and interstrand cross-links. It is generally accepted that the …

WebSep 28, 2024 · Using UVRR, we describe the binding interactions of two Pt (II) compounds, cisplatin (cis-diamminedichloroplatinum (II)) and its isomer, transplatin, with nucleotides and genomic DNA. Cisplatin binds to DNA and other cellular components and triggers apoptosis, whereas transplatin is clinically ineffective.

WebJul 25, 2002 · Cisplatin is a widely used anti-tumor agent that is used in the clinic to treat testicular and ovarian cancers . Cisplatin is believed to induce apoptosis in cancer cells by covalently modifying the DNA . Its geometric isomer, trans-[Pt(NH 3) 2 Cl 2] , has no … churches in the inland empireWebStereoisomers may possess differential biological activity, with S-(-)-ofloxacin and R-(þ)-ofloxacin (Atarashi et al. 1987), cisplatin and transplatin (Galea and Murray 2008), epirubicin and ... churches in thessalon ontarioWebDownload scientific diagram The chemical structures of cisplatin and transplatin. The main focus of this study is the mechanism of action of the DNA-damaging anti-cancer drug, cisplatin. churches in the kremlin moscowWebHowever, like cisplatin and transplatin, only the cis isomer has anti-cancer activity, whereas the trans-isomer does not. In order to understand the molecular basis of the different activities associated with cis-[Pt(NH3)2(4-Me-Py)Cl]+ and trans-[Pt(NH3)2(4-Me-Py)Cl]+, the interactions of these two platinum compounds with the DNA heptamer CCTG ... development stages of a teamWebAlthough transplatin molecule is more stable than cisplatin by 0.52 eV, we found cisplatin to be more favorable for reaction due to the following reasons: 1) the energy cost to remove a Cl atom is less from cisplatin than transplatin. churches in the heightsWebIn transplatin–DNA, there is a 3.4-fold decrease in the rate constant of the slow phase, compared with the cisplatin samples. This change is … churches in the kremlinWebNov 5, 2015 · The vibrational modes were investigated and assigned in detail for cisplatin and transplatin. The chemical reactivity of cisplatin and transplatin was analyzed by RDG, FMO and MESP analysis. The solvent effect on structures, IR spectra, and other properties was studied. development stage of year 1 maths