Web15 jun. 2005 · Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is … WebIn Hoxb7cre Tg/+ /Fgfr2 Lox/Lox tissues, we detected linear Fgfr2 expression only in stromal cells on either side of the nephric duct and ureteric bud epithelia (Fig. 6c).
Addgene: Cre-lox system
Web25 mrt. 2015 · The collecting system of the kidney develops from the ureteric bud (UB), which undergoes branching morphogenesis, a process regulated by multiple factors, … Web24 jun. 2010 · Deleting TβRII in the Collecting System Worsens Renal Injury after UUO. To define the role of TβRII in development of the renal collecting system, we deleted TβRII at the initiation of UB development (embryonic day 10.5) by crossing the Tgfbr2 flox/flox mouse on a ROSA26 reporter background with the Hoxb7Cre mouse. Strong β-galactosidase … multi supply international ltd
JCI Insight - Snapshots of nascent RNA reveal cell- and stimulus ...
Web1 jan. 2024 · Based on the finding that the collecting system of the Hoxb7cre:Itga6 flox/flox and Hoxb7cre:Itgb4 flox/flox mice developed dysplastic papillae over time, we tested the hypothesis that α6-containing integrins play a critical role in maintaining kidney structure following injury by subjecting them to unilateral ureteric obstruction (UUO). ). These … WebOur Hoxb7cre line has been shown to drive efficient deletion of Fgfr1, Fgfr2 and Frs2a in the UB (Sims-Lucas et al., 2009b; Zhao et al., 2004). For this study, Lox/LoxFgfr2[gift from Dr David Ornitz, Washington University, St Louis, MO, USA (Yu et al., 2003)] were bred with Frs2a Lox/Loxmice (Lin et al., 2007) to produce Fgfr2Lox/LoxFrs2a mice. WebContact ASN. 1401 H St, NW, Ste 900, Washington, DC 20005. [email protected]. 202-640-4660 multisurface boya