Rat's 2u
Tīmeklis1993. gada 1. marts · Based on cancer bioassays, hormone manipulation studies, investigations in an alpha 2u-g-deficient strain of rat, and other laboratory data, an increased proliferative response caused by chemically induced cytotoxicity appears to play a role in the development of renal tubule tumors in male rats. Thus, it is … Tīmeklis1990. gada 1. febr. · Alpha 2u-Globulin protein was demonstrable by immunoperoxidase method in all the pancreatic hepatocytes of male rats. Northern blot analysis confirmed the presence of 1.3 kb alpha 2u- globulin mRNA transcript in the pancreas of male rats with hepatocytes. Orchiectomy resulted in marked decrease of alpha 2u-globulin …
Rat's 2u
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TīmeklisBackground: alpha 2u-Globulin. alpha 2u -Globulin, also known as PGCL1, is a member of the Lipocalin family that show 87-98% amino acid sequence identity. alpha 2u -Globulin is the major urinary protein excreted by adult male rat. It is expressed at highest levels in male liver and coagulate glands.
Tīmeklis2024. gada 4. marts · Alpha-2u globulin nephropathy, a deposition of alpha-2u globulin (a lipocalin family protein with proteolytic and hydrolytic-resistant activities) in proximal tubule lysosomes, is an important toxicological syndrome that presents only in male rats and is relevant to nephropathy and renal neoplasia . Tīmeklis2024. gada 8. jūl. · Introduction. Alpha 2u-globulin is an adult male rat-specific low-molecular-weight (18 to 20 kDa) protein.The blood α 2u-globulin produced in the liver is filtered freely through the glomerulus, and about 60% of the filtered protein is reabsorbed by tubules 1.Certain chemicals bind noncovalently to α 2u-globulin, and the resultant …
TīmeklisWeinbren [see 1] characterised spontaneously occurring hyaline droplets in the otherwise normal mature male rat kidney. The ultrastructural characteristics of the spontaneous PCT hyaline body was characterised by Maunsbach as a phagolysosomal protein reabsorption droplet and defined as a male rat specific increased size and … Tīmeklisalpha 2u‑Globulin in Rat Kidney. a 2u -Globulin was detected in perfusion fixed frozen sections of rat kidney using Mouse Anti-Rat a 2u -Globulin Monoclonal Antibody …
Tīmeklisα 2u GLOBULIN is an androgen-dependent rat urinary protein with a molecular weight of about 23,800 (ref. 1). In the male rat, starting from puberty until senescence, α 2u …
Tīmeklis2024. gada 8. sept. · Unlike humans, rats have mammary tissue extending from the upper chest to the abdomen. There are other differences as well. Rats live only 2.5 to 3 years, 5 so the ratio of rat to human life span is 1 to 30. Rat skin lacks the outer keratinized layer that humans have, and is thin compared to that of humans. citi open women\u0027s singles matchesTīmeklis2003. gada 1. apr. · In summary, decalin inhalation exposure from 25 to 400 ppm for up to 13 weeks clearly induced male rat-specific α 2u-globulin nephropathy. Both decalin and 2-decalone accumulated in the male kidneys but not in female rat kidneys along with α 2u-globulin, suggesting that one or both of these compounds may bind to the … dibellas cranberry townshipTīmeklisFigure 1 Relative increases of mean renal α 2u-globulin concentrations, following 3-month exposures to decalin, propylene glycol mono-t-butyl ether (PGMBE), and Stoddard solvent IIC (SS IIC) to male rats; d-limonene-treated animals were exposed for 2 weeks.All rats (n = 10) were approximately 18 weeks old at the time of … dibellas nutritional informationTīmeklisIn a study in rats, this particular male-specific tendency correlated with increased renal expression of a small molecular weight drug-binding protein, alpha 2u-globulin. Male … citi outbound transfer limitTīmeklisA SEX dependent urinary protein in the rat has been described by Roy and Neuhaus 1–4.This protein is an α 2-globulin (α 2U) of hepatic origin and has a molecular … citi open watchTīmeklisMale and female F-344 rats were exposed to 0, 250, 450, or 1750 ppm TBA vapors 6 h/day for 10 consecutive days to assess alpha 2u-nephropathy and renal cell proliferation and for 1 and 8 days to evaluate the dosimetry of TBA following a single and repeated exposure scenario. dibellas east ave rochestestTīmeklis2024. gada 1. jūn. · Primary antibody (Rat α 2u-globulin-specific polyclonal goat IgG) was applied to the slide initially, and rinsed with buffer followed by the addition of secondary antibody (HRP-conjugated Rabbit Anti-Goat IgG). The sections were rinsed with buffer, the detection complex (DAB chromogen) was added and the sections … dibellas fairborn oh